This is one of the most anticipated games in the group stages and Ghana will be confident they can get something out of their clash against Portugal.
Ghana missed out on the 2018 World Cup but they are back with a bang and they are arguably the best team from Africa at the moment.
All eyes have been on Cristiano Ronaldo lately after his controversial interview that led to him parting ways with Manchester United.
Portugal will need the talisman to switch his focus if they are to better their round of 16 defeat to Uruguay at the 2018 tournament.
Despite their impeccable talent, Portugal have only made it to the semi finals of the World Cup on two occasions – in 1966 and 2006.
To make it worse, they have failed to make it past the round of 16 in four of their last 5 attempts but will be hoping for all that to change here.
All Africans will remember Luis Suarez of Uruguay denying the Black Stars the chance to progress to the semis 12 years ago and a revenge group stage game awaits them.
Ghana are expected to make it out of the group stage with Uruguay and South Korea the other two teams standing in their way.
A 2-0 victory over Switzerland in their final pre-tournament friendly will also give them the confidence boost they need ahead of the opener.
Will Portugal rise to the occasion and kick start proceedings with a win against Ghana?
Click here to make your predictions for the clash.
What time does Ghana vs Portugal start?
The game kicks off at 7pm Kenyan time at Stadium 974.
Ghana vs Portugal team news
Thomas Partey, Kamaldeen Sulemana and Alexander Djiku will all expect to come back into the side after being named on the bench against the Swiss.
Andre Ayew would become the highest appearance-maker for African players at a World Cup with 8 should he feature here but he may settle for a place on the bench.
His brother Jordan will definitely start as well as Athletic Bilbao forward Inaki Williams.
For the Portuguese, the defense will be commanded by Veteran Pepe and Manchester City duo of Ruben Dias and Joao Cancelo.
Ruben Neves and Manchester United’s Bruno Fernandes will start to control proceedings in midfield with the headache coming from the array of options up front.
Cristiano Ronaldo will captain the side being supported most likely by Rafael Leao and Bernardo Silva on opposite flanks.
Ghana vs Portugal head to head
The only match that has ever been played between these two sides in June 2014, ended 2-1 in favor of Portugal courtesy of a John Boye own goal and a Ronaldo goal.
Ghana vs Portugal current form
In terms of form leading up to the tournament, there is nothing separating these two sides who have both won 3 times and lost twice in their last 5 games.
Ghana vs Portugal prediction
Neither side lacks goals and with the attacking threat that they both possess, we can expect goals in this game.
Portugal are tipped as favorites to edge their opponents but it will not be an easy outing for the Selecao.