Ghana are looking to become the third African team to qualify for the knockout stages as they take on Uruguay in their final Group H clash.
The Black Stars come into the game in second place with 3 points behind leaders Portugal who take on South Korea in their final match.
Uruguay are bottom of the table with a point to their name following defeat to Portugal and a barren draw against South Korea.
This game is of utmost importance to the Africans as they are on a revenge mission after Uruguay dramatically knocked them out of the quarters in the 2010 World Cup.
Ghana can now eliminate Uruguay from the 2022 competition, having picked up three points from their opening two matches at the tournament.
They lost their section opener 3-2 to Portugal before recording a 3-2 victory over South Korea.
Uruguay, who famously won the World Cup in 1930 and 1950, finished fourth at the 2010 competition before reaching the round of 16 and quarters respectively in 2014 and 2018.
The South American nation have not actually been knocked out of a World Cup in the group stage since 2002, which was the first time that it had happened since 1974.
Will Ghana join Morocco and Senegal in the last 16 of the competition?
What time does Ghana vs Uruguay start?
The game kicks off at 6pm Kenyan time at the Al Janoub Stadium.
Ghana vs Uruguay team news
There are no injury concerns in the Ghanaian camp ahead of the clash and they are expected to field their strongest XI.
Mohamed Kudus scored twice in the last game and was impressive, he will retain his starting role.
Both brothers Jordan and Andre Ayew are also set to be part of the starting line-up, with Inaki Williams leading the attacking line.
Luis Suarez, who was at the center of the controversy in 2010, has not been a key feature in the Uruguayan squad but may be brought in here.
Darwin Nunez could potentially be joined in attack by Maxi Gomez, who was bright off the bench against Portugal, with Edinson Cavani potentially playing a role off the bench.
Ghana vs Uruguay head to head
That unforgettable match at the 2010 World Cup was the only game ever played between these two teams, with Uruguay winning 4-2 on penalties after a 1-1 draw.
Ghana vs Uruguay current form
The Black Stars have won three games in their last five and lost twice, against Portugal and Brazil, worthy enough opponents for them to have confidence going into this game.
While the South Americans have won twice, lost twice and shared the spoils in one game in that run.
Ghana vs Uruguay prediction
Both sides have enough quality in their sides to score goals and there will be from both teams. Though the Africa side are tipped as favorites to get revenge and win on the day.