Chelsea are hoping to knock Real Madrid out in two consecutive UCL campaigns when they battle it out in the quarters.
The holders knocked Madrid out of the semis last season, after a second leg win courtesy of goals from Timo Werner and Mason Mount.
The Blues beat Lille 4-1 to progress to this stage while Madrid staged a magnificent comeback win against French giants PSG.
Real are top of La Liga with a 12-point cushion, while Chelsea are in third place in the EPL despite a 4-1 loss to Brentford on Saturday.
This is the biggest tie scheduled in the UEFA Champions League quarters and record winners Real are out for revenge.
Who will come out on top in this first leg? Play here to make your predictions for the clash.
What time does Chelsea vs Real Madrid start?
The game kicks off at 10pm Kenyan time at Stamford Bridge.
Chelsea vs Real Madrid team news
The hosts are without Christian Pulisic, centre-back Trevoh Chalobah and England international Callum Hudson-Odoi.
Other than that there is a full squad for Thomas Tuchel to choose from, including Reece James who has recovered.
Kai Havertz, Mount and Werner are expected to be the front three selected to start the game.
Eden Hazard is out injured and will miss out on a return to his former employers and joins Luka Jovic on the sidelines.
Karim Benzema is in top form and will lead the attacking line alongisde Vinicius Junior and Marcos Asensio.
Chelsea vs Real Madrid head to head
Either side has won once, lost once and drawn another in the three matches played between these two sides.
Chelsea vs Real Madrid current form
There is nothing separating these two teams in terms of form, with both winning four times and losing just once in their most recent run of five games.
Chelsea vs Real Madrid prediction
Despite the recent loss over the weekend, the home team have what it takes to win the first leg albeit by a narrow margin.