Tottenham are seeking to bounce back to winning ways on Wednesday night when they host Southampton.
Antonio Conte’s side are coming back from a 2-0 league defeat to Chelsea, leaving them in 7th with 36 points.
Meanwhile, Southampton played out to a 1-1 draw against runaway league leaders Manchester City.
The Saints are in 12th place with 25 points.
Spurs eased past Brighton & Hove Albion 3-1 in the fourth round, while the Saints only just scraped past Coventry City 2-1 in the FA Cup.
Southampton did manage to hold Tottenham to a 1-1 draw on the South Coast back in December, but Spurs have won each of their last five home games against the Saints.
Play here to make your predictions for the clash.
What time does Tottenham vs Brighton start?
The game kicks off at 10:45pm Kenyan time at the Tottenham Hotspur Stadium.
Tottenham vs Brighton team news
New signings Dejan Kulusevski and Rodrigo Bentancur came off the bench in the last game and could also make an appearance from the start.
Up front Harry Kane will be supported by Son Heung-Min.
For the guests, Armando Broja is ruled out due to injury.
Moussa Djenepo is back from AFCON and could be returned to the starting line-up alongside Stuart Armstrong and Che Adams.
Tottenham vs Brighton head to head
From the 34 matches, Tottenham have come out on top 19 times compared to Southampton’s 10 wins.
The remaining 5 have resulted in a stalemate, including a 1-1 draw the last time they met.
Tottenham vs Brighton current form
Spurs have won thrice and lost two of their last five games while Southampton have only lost once in that run.
Tottenham vs Brighton prediction
Spurs have made some crucial new signings and they boast a better team on paper to be able to come out on top against their opponents.