AC Milan host Spanish league winners Atletico Madrid on Tuesday night, both hoping to get a first 2021/22 Champions League win.
The home side went down 3-2 to Liverpool on match day one, in a repeat of the legendary 2005 Istanbul final.
Meanwhile, Atletico were held to a barren draw by Porto, leaving them in second place in Group B.
Atletico boast a perfect record of two wins from their previous two clashes with AC Milan, claiming a 1-0 win at San Siro.
This was followed by a 4-1 home success in the last-16 of the 2013-14 tournament en route to the final.
AC Milan have experienced a resurgence under Stefano Pioli and will want to make their mark in Europe this season.
Play here to make your predictions for the clash as we have a look at both teams going into the midweek encounter.
What time does Milan vs Atletico start?
The game kicks off at 10pm Kenyan time at the San Siro.
Milan vs Atletico team news
Tiemoue Bakayoko, Rade Krunic, and Alessandro Florenzi remain injured for this fixture and Zlatan Ibrahimovic is not match fit.
Davide Calabria and Olivier Giroud are however ready to return to action and will be available for the hosts.
For the visitors, Thomas Lemar is the only injury concern and Stefan Savic remains absent as he serves a European ban.
Koke returned from injury over the weekend and could be handed a start in the Atletico midfield.
Antoine Griezmann and Luis Suarez are the most likely options to start up front.
Milan vs Atletico head to head
Atletico come into the match with the upper hand having won both games that these two clubs have played against each other.
Milan vs Atletico current form
The Italians are unbeaten in their last five league games, winning four times and drawing another. The only defeat came in the Champions League against Liverpool.
Atletico have lost just once in that run, winning twice and sharing the spoils in two games as well.
Milan vs Atletico prediction
Atletico have a resolute defense but it will be tough to contain Pioli’s side who have shown their capability to score goals. It should be a low scoring game but Milan may edge them on the night.