Despite a dismal run of games, leaders Juventus still maintain an eight-point gap at the summit of the Serie A table as they chase a 9th straight league title.
As for the hosts, a debut in the Europa League next season still seems mathematically possible depending on the remaining results from the six games left to play.
Ahead of the midweek fixture, here is all you need to know about both clubs.
What time does Sassuolo vs Juventus start?
The game is scheduled to kick off at 10:15 pm at the Mapei Stadium.
Sassuolo vs Juventus team news
Mert Muldur should return to the starting XI after being dropped for the 1-2 away victory at Lazio.
Francesco Caputo, who came off the bench to contribute a goal and assist might feature as well as the only other change to the Sassuolo line-up.
As for the Turin giants, Colombian Juan Cuadrado is out suspended and that should prompt Maurizio Sarri to bring in Danilo to play at right-back.
Sassuolo vs Juventus head to head
Juventus have scored an impressive 17 times against the hosts in their last five matches, compared to Sassuolo’s four goals.
Juve have gone on to win four of those matches which included a 7-0 demolition in February of 2018.
The reverse fixture in December 2019 resulted in a 2-2 draw and the hosts should not be completely written off as they continue their best-ever season in the top flight.
Sassuolo vs Juventus current form
The hosts come into the game on the back of a better run of form, having not lost a single game from their last 8 outings.
The last time they tasted defeat was a 4-1 loss at the hands of Atalanta, who were also responsible for the last time Juve dropped points in a 2-2 draw over the weekend.
Juventus are without a win in their last two games and need to change that if they are to secure the league title with a couple of games to spare.
Sassuolo vs Juventus prediction
Both teams have equally as much to gain from this game as the other, with one looking to extend their lead at the top and the other continues their quest for European football next season.
It is unlikely that Juventus will go three games without a win but what is almost a guarantee is both teams to find the back of the net.
Juventus has what it takes to edge their opponents in this game but will need to be more clinical if they are to achieve this.