Both teams come into the Saturday fixture looking to return to winning ways in the Bundesliga after both dropping points the last time they were in action.
Second-place RB Leipzig went down 3-1 at home to Borussia Dortmund whilst the hosts Wolfsburg were held to a 2-2 draw on the road by Union Berlin.
Wolfsburg are in sixth place with 25 points, six behind their opponents as they seek to reduce the point difference with victory on Saturday.
Both league meetings between Wolfsburg and RB Leipzig ended as draws last season, so with the form his side have displayed so far this season, Oliver Glasner may be urging his players to go one better on Saturday.
If they are to win their first ever Bundesliga title, RB Leipzig can surely not afford to lose any ground on Bayern, even with the Bavarians looking extremely vulnerable defensively at present.
What time does Wolfsburg vs RB Leipzig start?
The game will kick off at 5:30pm Kenyan time at the Volkswagon Arena.
Wolfsburg vs RB Leipzig team news
Joshua Guilavogui is set to return to the starting line-up to replace Arnold after he was sent off against Union Berlin.
Jeffrey Bruma, who has not been a key feature in the starting XI this season, could potentially be called upon for a rare start alongside John Anthony Brooks.
The visitors have a long list of injury concerns including Kevin Kampl, Christopher Nkunku, Marcel Sabitzer, Ibrahima Konate and Justin Kluivert.
Emil Forsberg will lead the attacking line flanked by Daniel Olmo and Alexander Sorloth.
Wolfsburg vs RB Leipzig head to head
The hosts have only won 3 out of the 13 matches played between these two sides, while Leipzig have managed 6 wins.
The remaining 4 matches have ended in a draw, including both games played last season, a 1-1 and barren draw in the league.
Wolfsburg vs Leipzig current form
Wolfsburg have won twice and lost twice in their last five outings, with their most recent result being the draw at Union Berlin.
As for the visitors, they have picked up 10 points in their last 5 games, winning thrice and registering another draw before the defeat to Dortmund last weekend.
Wolfsburg vs Leipzig prediction
There will not be a lack of goals in this highly anticipated encounter and both teams will definitely get their names on the scoresheet.
As for the final result, a draw is looking like the most likely outcome.