This Sunday night fixture comes at a great time for both teams who hammered their opponents in friendly matches three days ago.
Italy, who are top of the table with four points, destroyed Moldova 6-0 while Poland thrashed Finland 5-1 without the services of talisman Robert Lewandowski.
The Bayern Munich star returns for the game and his presence will need to be felt if Poland are to better their current third place standing.
If you want to pick sides, here is all the information you need to know about the game.
What time does Poland vs Italy start?
The game is set to kick off at 9:45 pm Kenyan time at the Stadion Energa Gdansk Stadium.
Poland vs Italy team news
Kamil Grosicki was sensational in midweek with a hat-trick and is expected to offer support to the returning Lewandowski in the Polish attack.
Unfortunately, Piotr Zielinski tested positive for coronavirus and he will most likely be replaced by Sebastian Szymanski.
It will be a tough decision for Roberto Mancini to make, especially after such a scintillating performance against Moldova which saw Brian Cristante and Domenico Berardi score their first goals for their country.
Stephen El Shaarawy also scored a brace and is expected to retain his place on the starting line-up.
Top scorer Ciro Immobile, who has 10 goals, should be the point man selected to start.
Poland vs Italy head to head
Italy are superior with 2 wins from 4 matches played between the two sides, including a 1-0 victory the last time they did two years ago.
Poland have won once and the other was a 1-1 draw in September 2018.
Poland vs Italy prediction
No doubt this will be an entertaining match and ideally one full of goals. Both teams will score but it’s tough to pick a winner.
With home advantage and Lewandowski returning, Poland could pull an upset.